Pysycache teach to use the mouse... so it works with the mouse! But some secure options are available for kids:
mouse can not go outside of the screen (in fullscreen mode): kids always show the mouse!
buttons of the activities are available after 2 seconds: to avoid kids clicking by mistake and making an action, buttons are active only for 2 seconds. To activate them, you have to put the mouse cursor over the button, and wait. After 2 seconds, button becomes bigger and then, you can click.
You can still use the keyboard for some usage:
ESC: in order to quit the current activity or Pysycache
F2: for displaying (or not) some buttons: in fact, kids doesn't have to use those buttons (according to their age and level).
The buttons visibility is the following: